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Exome Sequencing: Request a Quote

Questions? Please contact our Next Generation Sequencing (NGS) Team at [email protected], toll-free at 877-436-3949 ext. 1, or directly at +1-908-222-0711 ext. 1.

Do you want to submit a Sequencing Only Quote instead? Click Here

Frequently Asked Questions

1. How do I contact GENEWIZ for a technical consultation about my project?

GENEWIZ's NGS Team is composed of Ph.D. scientists who can help you optimize your project design and provide consultation to answer any questions. For any form questions that require support, the NGS Team can be contacted directly at [email protected], toll-free at 877-436-3949 ext. 1, or directly at +1-908-222-0711 ext. 1.

2. What is exome sequencing?

Exome sequencing is the targeted enrichment and subsequent sequencing of the whole exome. Exome sequencing is potentially the most powerful tool available to the research community for the identification of genetic variations associated with a phenotype, such as a disease.

3. What is the advantage of exome sequencing compared to whole genome sequencing?

Whole genome sequencing requires an extremely high amount of sequencing throughput to generate even a moderate depth of coverage. The data generated, while comprehensive, will not allow detection of mutations with as much sensitivity as a targeted approach. Paired with current sequencing technologies, exome sequencing is the most cost-effective and efficient solution.

A large portion of relevant mutations occur in the exome. In fact, the exome contains as many as 85% of disease-related mutations. Covering less than 2% of the whole genome, exome sequencing requires only 1/50th of the sequencing throughput to generate the same depth of coverage. The lower sequencing throughput required by exome sequencing provides flexible experimental options:

1. Maintain the same depth of coverage and multiplex more samples into the same lane, significantly decreasing total project cost;

2. Increase the depth of coverage to facilitate the detection of rare, low-frequency mutations;

3. Any combination of 1 and 2.

4. What bioinformatic services are available for exome sequencing projects?

We provide raw data as FASTQ files for all projects. We also have advanced bioinformatics capabilities to provide optional data analysis services, including:

  • Standard DNA Analysis package- includes mapping, and SNP/Indel discovery
  • CNV discovery

5. Why choose GENEWIZ for exome sequencing projects?

We have proven our steadfast commitment to superior service throughout the years, becoming established as a global leader in DNA sequencing and genomics. Further, we have extensive experience and expertise in next generation sequencing techniques, including exome sequencing. An expert Project Manager can assist you in determining specifications for optimizing your project.

6. Can GENEWIZ recommend the best data delivery option?

Yes, GENEWIZ will recommend the best data delivery option based on the platform and project details. Data delivery options include:

  • Secure File Transfer Protocol (SFTP)
  • Customer Cloud Account
  • Hard Drive (additional charges may apply)
  • Other (please explain in additional comments section