About the tech note
Integrity of the inverted terminal repeat (ITR) regions of adeno-associated virus (AAV) transfer plasmid is crucial for rAAV production. Truncated ITRs can reduce the yield of full viral capsid production and increase generation of undesirable non-rAAV encapsidated DNA. GENEWIZ’s proprietary AAV plasmid preparation process significantly improves the chance of maintaining ITR integrity, and can also isolate clones with full-length ITRs from a sample mixture containing intact and truncated ITRs.
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