The Long and Short of AAV Sequencing:
Enhancing Gene Therapy Pipelines with Orthogonal Analysis

The Long and Short of AAV Sequencing: Enhancing Gene Therapy Pipelines with Orthogonal Analysis

In the rapidly evolving field of gene therapy, sequencing technologies play a critical role in advancing research and development from molecular design to IND applications. Each sequencing platform, long- and short-read, offers unique strengths that address specific challenges and questions in the gene therapy workflow. This article explores how these technologies can complement each other and their critical role in the gene therapy landscape. By understanding their unique strengths and economic trade-offs, you’ll discover how to strategically deploy these tools to achieve robust results.

This article covers:

• Comparison of library preparation and sequencing workflows across platforms
• Understanding sample preparation and detection bias between sequencing technologies
• Maximizing sequencing platforms to enhance the AAV therapy development pipeline