Guide to RNA Therapeutics
RNA therapeutics are transforming medicine, from mRNA vaccines to gene-silencing drugs. This eBook from GENEWIZ by Azenta Life Sciences offers a practical overview of the RNA therapy landscape and the science behind effective design, mRNA synthesis via in vitro transcription (IVT), and quality control (QC), so you can move from concept to clinically relevant data with confidence.
What You’ll Learn
- The therapeutic mechanisms behind RNA types, including mRNA, siRNA, ASOs, aptamers, and circRNA
- Structural elements of therapeutic mRNA, and how 5' caps, UTRs, codon optimization, and poly(A) tails affect stability and translation
- Best practices for mRNA production, using integrated gene synthesis and in vitro transcription workflows
- Advanced QC strategies, including full-length RNA sequencing to assess transcript integrity, poly(A) tail length, and product purity
- Clinical and emerging applications, from FDA-approved RNA drugs to cancer vaccines and treatments for rare neurological disease therapeutics
Elevate Your RNA Therapy R&D
Whether you’re new to RNA drug development or refining mRNA/circRNA pipelines, this guide delivers actionable strategies for design, synthesis, and QC, helping you streamline workflows, increase reproducibility, and accelerate therapeutic discovery.
