A Guide to RNA Therapeutics

What You'll Learn

• The therapeutic mechanisms behind RNA types, including mRNA, siRNA, ASOs, aptamers, and circRNA

• Structural elements of therapeutic mRNA, and how 5' caps, UTRs, codon optimization, and poly(A) tails affect stability and translation

• Best practices for mRNA production,  using integrated gene synthesis and in vitro transcription workflows

• Advanced QC strategies, including full-length RNA sequencing to assess transcript integrity, poly(A) tail length, and product purity

• Clinical and emerging applications, from FDA-approved drugs to cancer vaccines and treatments for rare neurological diseases