--- title: GEM-X Single-Cell Tech Note | GENEWIZ from Azenta description: Discover how the new GEM-X chemistry from 10x Genomics improves the performance of single-cell RNA sequencing (scRNA-seq) in this detailed tech note. --- [Skip to content](https://web.genewiz.com/tech-note/gem-x-single-cell-tech-note#main-content) [![GENEWIZ](https://web.genewiz.com/hubfs/GENEWIZ%20Brand%20Assets/GENEWIZ%20Logos/2025-04%20Current%20GENEWIZ%20Logos/GENEWIZ_Full-Color_Logo_PublicWeb_200x63.svg "GENEWIZ")](https://www.genewiz.com/) English # Enhanced Gene Detection with GEM-X Single-Cell RNA Sequencing TECH NOTE ## Enhanced Gene Detection with GEM-X Single-Cell RNA Sequencing Discover how the new GEM-X chemistry from 10x Genomics® improves the performance of **single-cell RNA sequencing (scRNA-seq)** in this detailed tech note. By comparing **Next GEM® and GEM-X single-cell sequencing kits**, we highlight key performance advancements introduced with GEM-X, including improvements in **cell recovery, gene detection sensitivity, and reproducibility**. These enhancements position GEM-X as a powerful solution for **high-throughput single-cell sequencing, delivering greater precision and efficiency without increasing cost per cell.** ### What You'll Learn - Discover how **GEM-X single-cell RNA-seq chemistry** enhances experimental performance through a direct comparison with **Next GEM** technology. - Explore key performance metrics, including **cell recovery, reduced doublet rates, and improved gene detection**, that demonstrate the efficiency of GEM-X sequencing. - Understand how **GEM-X reproducibility across replicates and enhanced immune cell profiling** improve overall data quality and reliability for downstream analysis. ![13021-ATN LP Thumbnail](https://web.genewiz.com/hs-fs/hubfs/TECH%20NOTES%202026/13021-ATN%20LP%20Thumbnail.png?width=884&height=1000&name=13021-ATN%20LP%20Thumbnail.png "13021-ATN LP Thumbnail") ## Download Tech Note ## Related Services [Single-cell Sequencing](https://www.genewiz.com/public/services/next-generation-sequencing/illumina-sequencing) High-resolution transcriptomic profiling from individual cells to reveal cellular heterogeneity [Single-cell Library Sequencing Only](https://www.genewiz.com/public/services/next-generation-sequencing/illumina-sequencing) High-quality sequencing of pre-prepared single-cell libraries with fast, reliable data delivery. [RNA Sequencing](https://www.genewiz.com/public/services/next-generation-sequencing/whole-genome-sequencing) Comprehensive transcriptome profiling to quantify gene expression and transcript diversity.