--- title: Olink® Proteomic Biomarker Discovery Tech Note | GENEWIZ from Azenta description: In this tech note, discover the science behind this novel assay and how it’s an optimal approach for quality control for the development of your mRNA-based vaccines or drugs. --- [Skip to content](https://web.genewiz.com/tech-note/olink-proteomic-biomarker-discovery#main-content) [![GENEWIZ](https://web.genewiz.com/hubfs/GENEWIZ%20Brand%20Assets/GENEWIZ%20Logos/2025-04%20Current%20GENEWIZ%20Logos/GENEWIZ_Full-Color_Logo_PublicWeb_200x63.svg "GENEWIZ")](https://www.genewiz.com/) English # Olink Proteomic Biomarker Discovery Tech Note TECH NOTE ## Proteomic Biomarker Discovery to Support Clinical Trials Using High Plex Olink PEA Technology Historically, **preclinical exploratory research** and **clinical trial biomarker detection** have been restricted to a limited number of protein indicators measured by **mass spectrometry** and **ELISA (enzyme-linked immunosorbent assay)**. These traditional approaches often constrain the ability to evaluate complex biological responses across multiple pathways due to limited plex capacity and higher sample requirements. Using **Olink® Proximity Extension Assay (PEA) technology, GENEWIZ from Azenta Life Sciences** delivers **fully validated protein biomarker discovery services** that enable **higher-plex and scalable protein analysis** with sensitivity comparable to traditional methods while requiring **low sample input**. This approach expands access to **multiplexed protein biomarker data**across **preclinical research and clinical trial programs**. In this tech note, explore the science behind the **Olink PEA assay** and learn how this optimized workflow makes it easier to incorporate **protein biomarker discovery** into **preclinical and clinical research**.   ### What You'll Learn - Discover how **high-plex proteomics** supports **protein biomarker discovery** across **preclinical research and clinical trials** - Explore the capabilities of **multiplexed and high-plex Olink Target Panels** for **cytokine and inflammatory biomarker profiling** - Review results from **GENEWIZ’s supplementary validation study** of the **Olink Target 48 Cytokine assay**, including **assay precision, reproducibility, and performance metrics** ![13019-ATN-2 LP Thumbnail](https://web.genewiz.com/hs-fs/hubfs/TECH%20NOTES%202026/13019-ATN-2%20LP%20Thumbnail.png?width=884&height=1000&name=13019-ATN-2%20LP%20Thumbnail.png "13019-ATN-2 LP Thumbnail") ## Download Tech Note ## Related Services [Olink Proteomics Services](https://www.genewiz.com/public/services/next-generation-sequencing/proteomics) High-sensitivity protein biomarker profiling using proximity extension assay technology. [Clinical Services](https://www.genewiz.com/public/services/clinical-services) Regulatory-compliant laboratory testing to support clinical research and trials. [RNA Sequencing](https://www.genewiz.com/public/services/next-generation-sequencing/whole-genome-sequencing) Comprehensive transcriptome profiling to quantify gene expression and transcript diversity.